Lower miR-21/ROS/HNE levels associate with lower glycemia after habit-intervention: Diapason study 1-year later

Background and Aims : The prevalence of prediabetes is increasing in the global population its metabolic derangements may expose to a higher risk develop type 2 diabetes (T2D) cardiovascular burden. Lifestyle modifications might have considerable benefits on ameliorating status. Alternative biomarkers, such as circulating miR-21, has been recently discovered associated with dysglycemia. Current evidences demonstrated that miRs predict progression from pre-diabetic state. Here we evaluated, longitudinal cohort dysglycemic relation between miR-21/ROS/HNE levels lifestyle changes after 1 year follow-up.Methods: 1506 subjects DIAPASON study were screened basis Findrisc score. 531 ≥9 selected for dysglycemia (ADA criteria) tested ROS HNE levels, damaging-axis. 207 re-evaluated habit-intervention (HI), 1-year later. Repeated measures tests used evaluate changes. Furthermore, linear regression logistic models implemented association glycemic parameters miR-21/ROS/HNE.Results: We observed, HI,significant reduction axis subjects, concomitantly parameters.Significant positive interaction was observed miR-21 glycaemic HI. Lower HI, strongly damaging-axis, particular within values 2hPG<200 mg/dL.Conclusions: Our findings HI influenced epigenetic related axis. These data support usefulness novel biological approaches monitoring glycemia well provide screening tool preventive programmes. follow-up. Methods: miR-21/ROS/HNE. Results: mg/dL. Conclusions: